Die chronologische Liste zeigt aktuelle Veröffentlichungen aus dem Forschungsbetrieb der Hochschule Weihenstephan-Triesdorf. Zuständig ist das Zentrum für Forschung und Wissenstransfer (ZFW).
8 Ergebnisse
Gustavo Chaves,
Artem G. Ayuyan,
Vladimir V. Cherny,
Deri Morgan,
Arne Franzen,
Lynne Fieber,
Prof. Dr. Lydia Nausch,
Christian Derst,
Iryna Mahorivska,
Christophe Jardin,
Thomas E. DeCoursey,
Boris Musset
Voltage-gated ion channels, whose first identified function was to generate action potentials, are divided into subfamilies with numerous members. The family of voltage-gated proton channels (HV ) is tiny. To date, all species found to express HV , have exclusively one gene that codes for this unique ion channel. Here we report the discovery and characterization of three proton channel genes in the classical model system of neural plasticity, Aplysia californica. The three channels (AcHV1, AcHV2, AcHV3) are distributed throughout the whole animal. Patch-clamp analysis confirmed proton selectivity of these channels but they all differed markedly in gating. AcHV1 gating resembled HV in mammalian channels where it is responsible for proton extrusion and charge compensation. AcHV2 activates more negatively and conducts extensive inward proton current, properties likely to acidify the cytosol. AcHV3, which differs from AcHV1 and AcHV2 in lacking the first arginine in the S4 helix, exhibits proton selective leak currents and weak voltage dependence. We report the expansion of the proton channel family, demonstrating for the first time the expression of three functionally distinct proton channels in a single species.
Mehr
Norman Gentsch,
Diana Heuermann,
Jens Boy,
Steffen Schierding,
Prof. Nicolaus von Wirén,
Dörte Schweneker,
Dr. Ulf Feuerstein,
M.Sc. Robin Kümmerer,
Prof. Dr. Bernhard Bauer,
Prof. Dr. Georg Guggenberger
Dr. Annette Bucher,
B.Sc. Lena Fröhler,
Prof. Dr. Michael Beck,
Viola Stiele,
Dipl. Ing. (FH) Hans-Peter Haas,
Thomas Lohrer,
Katrin Kell,
Dieter Neumaier,
Gisela Westermeier,
Marianne Scheu-Helgert,
Hubert Siegler,
Lutz Popp
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