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Veröffentlichungen der HSWT

Die chronologische Liste zeigt aktuelle Veröffentlichungen aus dem Forschungsbetrieb der Hochschule Weihenstephan-Triesdorf. Zuständig ist das Zentrum für Forschung und Wissenstransfer (ZFW).

8 Ergebnisse

  • Maren Bernau, Sebastian Schwanitz, Prof. Dr. Prisca Kremer-Rücker, Lena Sophie Kreuzer, Prof. Dr. Armin Manfred Scholz

    • Berechtigungen:  Open Access
    • Berechtigungen:  Peer Reviewed

    Size matters: Boar taint in relationship with body composition and testis volume measured by magnetic resonance imaging (2018) Livestock Science 213 , S. 7-13. DOI: 10.1016/j.livsci.2018.04.008

  • Elena Castellanos-Rizaldos, Prof. Dr. Dominik Grimm, Vasisht R. Tadigotla, James Hurley, John Healy, Patricia L. Neal, Mia Sher, Raajdeep Venkatesan, Chris Karlovich, Mitch Raponi, Anne Krug, Mikkel Noerholm, Jihane Tannous, Bakhos A. Tannous, Luis E. Raez, Johan K. Skog

    • Berechtigungen:  Open Access
    • Berechtigungen:  Peer Reviewed

    Exosome-Based Detection of EGFR T790M in Plasma from Non–Small Cell Lung Cancer Patients (2018) Clinical Cancer Research 24 (12), S. 2944-2950. DOI: 10.1158/1078-0432.CCR-17-3369

    Purpose: About 60% of non–small cell lung cancer (NSCLC) patients develop resistance to targeted epidermal growth factor receptor (EGFR) inhibitor therapy through the EGFR T790M mutation. Patients with this mutation respond well to third-generation tyrosine kinase inhibitors, but obtaining a tissue biopsy to confirm the mutation poses risks and is often not feasible. Liquid biopsies using circulating free tumor DNA (cfDNA) have emerged as a noninvasive option to detect the mutation; however, sensitivity is low as many patients have too few detectable copies in circulation. Here, we have developed and validated a novel test that overcomes the limited abundance of the mutation by simultaneously capturing and interrogating exosomal RNA/DNA and cfDNA (exoNA) in a single step followed by a sensitive allele-specific qPCR.Experimental Design: ExoNA was extracted from the plasma of NSCLC patients with biopsy-confirmed T790M-positive (N = 102) and T790M-negative (N = 108) samples. The T790M mutation status was determined using an analytically validated allele-specific qPCR assay in a Clinical Laboratory Improvement Amendment laboratory.Results: Detection of the T790M mutation on exoNA achieved 92% sensitivity and 89% specificity using tumor biopsy results as gold standard. We also obtained high sensitivity (88%) in patients with intrathoracic disease (M0/M1a), for whom detection by liquid biopsy has been particularly challenging.Conclusions: The combination of exoRNA/DNA and cfDNA for T790M detection has higher sensitivity and specificity compared with historical cohorts using cfDNA alone. This could further help avoid unnecessary tumor biopsies for T790M mutation testing.

  • Prof. Dr. habil. Carsten Lorz, M. Heckner

    • Berechtigungen:  Peer Reviewed

    The Training Forest Trail of the Department of Forestry, Hochschule Weihenstephan-Triesdorf, University of Applied Sciences, Germany (2018) SILVA 2018 Technische Universität Dresden, Tharandt, Sächsische Landesbibliothek − Staats- und Universitätsbibliothek, Dresden 2018 .

  • Johannitag HSWT (2018) Infostand des Biomasse-Instituts (BIT) am 24. Juni 2018 .

  • Jan M. Falcke, Neelanjan Bose, Alexander B. Artyukhin, Christian Rödelsperger, Gabriel V. Markov, Joshua J. Yim, Prof. Dr. Dominik Grimm, Marc H. Claassen, Oishika Panda, Joshua A. Baccile, Ying K. Zhang, Henry H. Le, Dino Jolic, Frank C. Schroeder, Ralf J. Sommer

    • Berechtigungen:  Open Access
    • Berechtigungen:  Peer Reviewed

    Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis (2018) Cell Chemical Biology 25 (6), S. 787-796. DOI: 10.1016/j.chembiol.2018.04.004

    In the nematodes Caenorhabditis elegans and Pristionchus pacificus, a modular library of small molecules control behavior, lifespan, and development. However, little is known about the final steps of their biosynthesis, in which diverse building blocks from primary metabolism are attached to glycosides of the dideoxysugar ascarylose, the ascarosides. We combine metabolomic analysis of natural isolates of P. pacificuswith genome-wide association mapping to identify a putative carboxylesterase, Ppa-uar-1, that is required for attachment of a pyrimidine-derived moiety in the biosynthesis of ubas#1, a major dauer pheromone component. Comparative metabolomic analysis of wild-type and Ppa-uar-1 mutants showed that Ppa-uar-1 is required specifically for the biosynthesis of ubas#1 and related metabolites. Heterologous expression of Ppa-UAR-1 in C. elegans yielded a non-endogenous ascaroside, whose structure confirmed that Ppa-uar-1 is involved in modification of a specific position in ascarosides. Our study demonstrates the utility of natural variation-based approaches for uncovering biosynthetic pathways.

  • F. Neubacher, Prof. Dr. Anja Faße, Prof. Dr. Ulrike Grote

    • Berechtigungen:  Peer Reviewed

    Viktimisierung und Kriminalitätsfurch im ländlichen Tansania (2018) Monatsschrift für Kriminologie und Strafrechtsreform 100 (4), S. 272-290. DOI: 10.1515/mkr-2017-1000404

  • Katrin Reincke, Elisa Vilvert, Prof. Dr. Anja Faße, Frieder Graef, Stefan Sieber, Marcos Alberto Lana

    • Berechtigungen:  Open Access
    • Berechtigungen:  Peer Reviewed

    Key factors influencing food security of smallholder farmers in Tanzania and the role of cassava as a strategic crop (2018) Food Security 10 , S. 911-924. DOI: 10.1007/s12571-018-0814-3

  • Prof. Dr. Michael Tröster, Prof. Dr. Johannes Sauer

    • Berechtigungen:  Peer Reviewed

    Integration of transport costs into a cost function for fertilizer application (2018) Northern American Productivity Workshop X (June 12-15, 2018), Miami Business School, Miami, USA. .

Betreuung der Publikationsseiten

Zentrum für Forschung und Wissenstransfer - Lageplan in Weihenstephan an der HSWT

Kontakt

Hochschule Weihenstephan-Triesdorf
Zentrum für Forschung und Wissenstransfer
Gebäude H21
Am Staudengarten 9
85354 Freising

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