Die chronologische Liste zeigt aktuelle Veröffentlichungen aus dem Forschungsbetrieb der Hochschule Weihenstephan-Triesdorf. Zuständig ist das Zentrum für Forschung und Wissenstransfer (ZFW).
Medria Shekar Rani,
Prof. Dr. Eckart Lange,
Prof. Dr. Ross Cameron,
Prof. Dr. Olaf Gerhard Schroth
Berechtigungen: Open Access
Berechtigungen: Peer Reviewed
An Interactive Landscape Planning Process for Sustaining Flood Regulation in the Ci Kapundung Upper Water Catchment Area , Bandung Basin , Indonesia. (2019)
DOI: 10.14627/537663004
Simulations and modelling are often used in many studies to assess and visualise the effects of landscape changes on environment. However, only a few studies have been conducted to assess landscape interventions to sustain ecosystem services, including hydrological processes. This paper presents an iterative and interactive process to generate landscape planning for the Ci Kapundung upper water catchment area, Bandung Basin, Indonesia, based on two development scenarios. The land change model was coupled with a hydrological model to assess the influence of land cover changes on flood risk in Bandung Basin. The result shows that the overland flow at three observation points is affected by the land cover, topography, and soil properties. Outputs from the iterative hydrologic sim- ulations suggested that conifers could be planted in the proposed river buffers in the case study area to reduce the volume of runoff flowing to the Ci Kapundung River.
Debarking Head im Hunsrück - Vollmechanisierte Holzernte mit gleichzeitiger Entrindung (2019) FTI Forsttechnische Informationen, hrsg. vom Kuratorium für Waldarbeit und Forsttechnik e.V. 2019 (4), S. 14-15.
Eike Stefan Dobers,
Prof. Dr. Patrick Noack
Farbkleckse mit Mehrwert (2019) BAUERNZEITUNG, 18. WOCHE 2019 , S. 24-26.
Elena Castellanos-Rizaldos,
Xuan Zhang,
Vasisht R. Tadigotla,
Prof. Dr. Dominik Grimm,
Chris Karlovich,
Luis E. Raez,
Johan K. Skog
Berechtigungen: Open Access
Berechtigungen: Peer Reviewed
Exosome-based detection of activating and resistance EGFR mutations from plasma of non-small cell lung cancer patients (2019) Oncotarget 10 (30), S. 2911-2920.
DOI: 10.18632/oncotarget.26885
Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer and its molecular landscape has been extensively studied. The most common genetic alterations in NSCLC are mutations within the epidermal growth factor receptor (EGFR) gene, with frequencies between 10-40%. There are several molecular targeted therapies for patients harboring these mutations.Liquid biopsies constitute a flexible approach to monitor these mutations in real time as opposed to tissue biopsies that represent a single snap-shot in time. However, interrogating cell free DNA (cfDNA) has inherent biological limitations, especially at early or localized disease stages, where there is not enough tumor material released into the patient’s circulation.We developed a qPCR- based test (ExoDx EGFR) that interrogates mutations within EGFR using Exosomal RNA/DNA and cfDNA (ExoNA) derived from plasma in a cohort of 110 NSCLC patients.The performance of the assay yielded an overall sensitivity of 90% for L858R, 83% for T790M and 73% for exon 19 indels with specificities of 100%, 100%, and 96% respectively. In a subcohort of patients with extrathoracic disease (M1b and MX) the sensitivities were 92% (L858R), 95% (T790M), and 86% (exon 19 indels) with specificity of 100%, 100% and 94% respectively.
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